Monototal ELISA
MonoTotal® assay determines soluble fragments of cytokeratin 19, 8 and, at certain extent, cytokeratin 18 in serum. The size of the determined cytokeratin fragments is in the range of 10-500 kDa. It is used as a marker of tumor activity reflecting malignant tissue degradation and cell necrosis in epithelial cell carcinomas, particularly in Non-small cell lung cancer.