Estrone
Estrone (E1) is one of the three major naturally-occurring estrogens. It is principal estrogene in women after menopause, when ovarian production of estradiol ceases. The determination of estrone can be used in the assessment of fertility status and sexual development. It can be used in monitoring hormone replacement therapy in postmenopausal women. It can be also useful as an aid in diagnosis of precocious and delayed puberty in girls and as an aid in diagnosis of disorders of sex steroid metabolism (e.g. aromatase deficiency and 17α-hydroxylase deficiency).