Androstanediol glucuronide
3α-androstanediol glucuronide is a product of androgens degradation, particularly by intracellular reduction of DHT. Its determination is used in management of diseases with excessive androgen production. It reflects skin androgen activity, which is dependent on the presence of 5α-reductase enzyme, converting testosterone to DHT. Accordingly, the measurement of 3α-androstanediol glucuronide is an indirect way of testing DHT and 5α-reductase activity. The determination of 3α-androstanediol glucuronide can be used as an aid in diagnosis of androgen-related endocrine disorders.