Cyclosporine direct
Cyclosporine A is a cyclic peptide which has marked immunosuppressive effect, affecting above all the T-cell production and thus the immune response of the organism. It is used to prevent rejection of graft in patients after transplantation. Because of Cyclosporine A toxicity, the therapeutically tolerable range is relatively narrow and drug concentration in patient's blood after transplantation must be regularly checked. The determination of cyclosporine A ican be used to monitor cyclosporine therapy.